On disk 1 go to 'Special Features' then 'Character Files'. Wth the exeption of Uncle Ben, when on the second page of each actors filmography press up and enter to reveal their comic book profile.
On disk 1go to the 'Commentaries' menu then hightlight the special features option an press left and a spider will appear on screen. Press enter to view "CGI Bloopers"
On disk 2 go to the DVD-ROM feature and press the UP arrow and a Spidey icon will appear. Press enter to view an exclusive interview with Todd McFarlane talking about how Spidey makes his webs.
On disk 2, go to the evolution of spider-man, then choose the rogue's gallery. Go to Electro, at the menu button (spidey logo) press down, you'll highlight a spidey sillhouette. Select it and you'll get the full screen version of the 3D Electro. It works also for Venom and Scorpion.
On disk 2 go to the comic book section and choose the "evolution of spider-man" option, then go to "rogues gallery". Once you are there, at the top you will see a picture of Spidey with his spidey sense tingling. Press up until his spidey sense highlights, press enter and you will get a page on "the sinister six" with information and 3D photos.
On disk 2 select the "Web of Spider-Man" option, and then "The Evolution of Spider-Man". Once in this menu, select "Artists Gallery" and press the RIGHT button. The words "The Romitas" will appear at the upper right corner of the screen. Select them, and check out a nice video feature on the comicbook artists John Romita Sr. and John Romita Jr.
On disk 2 select the "Comic Book Artist Gallery" from the "Artist Gallery" section. As you browse the gallery, look for the one done by Terry Dodson (it's a black and white drawing). Highlight the camera that is used for navigating and press up. You'll see Terry Dodson's signature on the spider-man drawing. Press there and you'll be taken to another gallery that contains famous spider-man comic book covers, except that they are re-drawn with the spider-man movie costumes and faces.
This easter egg was generously submitted/corrected by spikey2000
Insert the first disc of the DVD set and go to 'Special Features' ,select entry for 'Commentaries' and in the following screen highlight the option 'Technical Commentaries Off.' Now, press the 'Right' arrow key on your remote followed by the 'Up' key. Now press 'enter' and you will get to see Sam Raimi's Promo for Japanese audiences.
Next insert the 2nd disc of the set and select the menu entry for the 'Making the Amazing' documentary. On the next screen highlight the 'Play All' and then press the 'Up' arrow key on your remote. This will take you to a clip of a practical joke being played on Alfred Molina by a cast member.
Now go to the 'Gallery' section of the disc, accessible from the 'Special Features' menu. There, highlight the menu entry 'Proceed' and then press the 'Up' arrow key on your remote. This will highlight a spider and give you access to a clip of Alfred Molina taking a break from an intense scene of portraying Doc Ock.
This easter egg was generously submitted/corrected by DougieB